New drug could prevent heart attacks

 
Related

5 key reasons why parenting is in crisis right now

About everything
428 points

This mix will prevent strokes, heart attacks and much more!

About everything
466 points



Most recent

Un día, un rato, grandes momentos de amor. Las amé a todas

Enrique TF-Relatos
8 points

Ese momento esencial

Enrique TF-Relatos
8 points

La ceguera de Saramago y la alegría de vivir

Enrique TF-Relatos
8 points

El INFOTEP realiza una investigación sobre el diagnóstico ambiental del Manantial de Cañaverales.

Alcibiades Nuñez
54 points

Esperanza: Ven a robarme a mi

Enrique TF-Relatos
8 points

Pone fecha al fin de la Pandemia de la COVID-19, uno de los creadores de la vacuna de Pfizer

Enrique TF-Noticias
18 points

Anna Olson Recetas para invitados se emite en Colombia

Avant Garde
8 points

MENSAJE A LA OPINION PÚBLICA EN TIEMPOS DE TURBULENCIA SOCIAL

pensamiento Libre
90 points

Alarma: El cambio climático ha cambiado ya el eje de giro de la Tierra

Enrique TF-Noticias
36 points

PASTUSOS SI NO QUEREIS LA ESTATUA DE ANTONIO NARIÑO AHÍ LA TENEIS

pensamiento Libre
100 points
SHARE
TWEET
A drug that stops blockages from forming in blood vessels could be a new way to prevent heart attacks and strokes.

New drug could prevent heart attacks

“Arteries are living hoses that narrow and enlarge in order to regulate blood flow to organs and muscles,” says William Fay from the University of Missouri School of Medicine and senior author of the study published in Arteriosclerosis, Thrombosis, and Vascular Biology. “Smooth muscle cells in the artery regulate blood flow by constricting and relaxing. However, when chronic inflammation occurs in a blood vessel―typically in response to diabetes, high cholesterol, and cigarette smoking―the smooth muscle cells in the walls of arteries change their behavior.

“They gradually accumulate inside the artery and narrow the blood vessel. In the case of coronary arteries, which supply blood to heart muscle cells, this process produces blockages that can lead to a heart attack.”

Plasminogen activator inhibitor-1, or PAI-1, is a naturally occurring protein within blood vessels that controls cell migration. With diseases such as diabetes and obesity, PAI-1 over-accumulates in blood vessels. This promotes blockage formation.

This process occurs not only in arteries, but also in vein grafts in patients who have undergone coronary artery bypass graft surgery.

Decreased blockages by 50%

Fay’s research team studied PAI-039, also known as tiplaxtinin, an investigational drug not yet used to treat humans. The researchers found that PAI-039 inhibited the migration of cultured human coronary artery smooth muscle cells, and prevented the development of blockages in arteries and bypass grafts in mice.

“We found that PAI-039 decreased blockage formation by about 50 percent, which is a powerful effect in the models we used,” says Fay, who also serves as a research scientist at the Harry S. Truman Memorial Veterans’ Hospital in Columbia, Missouri. “In addition to reducing vascular blockages, inhibiting PAI-1 also produces a blood thinning effect that prevents the blood clots that trigger most heart attacks and strokes.”

Fay hopes that if future studies are successful, PAI-039 or similar drugs could be used to prevent blockages in arteries and bypass grafts.

“I don’t think there will be any one ‘magic pill’ that prevents arterial diseases, especially for those with other high-risk conditions,” Fay says. “However, perhaps someday a PAI-1 inhibitor can be used in combination with other approaches such as proper diet and exercise, aspirin, and cholesterol medications to prevent blood vessel blockages and reduce heart attack and stroke risk.”

The National Institutes of Health and the Department of Veterans Affairs supported the study.



Fuente: www.futurity.org
SHARE
TWEET
To comment you must log in with your account or sign up!

Comentarios más recientes
fipepegada
I be certain ...that...my best friend had been realie taking h0me money part-time on their apple laptop. . there friend brother haz done this 4 less than 10 months and as of n0w paid the loans on their h0me and bourt a brand new Cadillac . look at this +_+_+_+_+_+_+_+_+ http://www.homejobs7.com
 
zelupatif
Work oppertunity: Start your work at home right now. Spend more time with your family and earn. Start bringing 85USD/­­­hr just on a laptop. Very easy way to make your life happy and earning continuously.last week my check was 24551USD pop over here this site +_+_+_+_+_+_+_+_+ http://www.homejobs7.com
 
Tahedra Koc
HAPPY NEW YEARS Peyton . you think Connie `s blog is cool, I just purchased BMW M3 from having made $4287 this-last/5 weeks an would you believe ten-k last month . it's by-far my favourite-work I've ever had . I began this 8-months ago and straight away startad earning more than $72, per-hr . visit the website ................................ http://www.wagenet10.com
 
poyazilele
Facebook gives you a great opportunity to earn 98652$ at your home.If you are some intelligent you makemany more Dollars.I am also earning many more, my relatives wondered to see how i settle my Life in few days thank GOD to you for this...You can also make cash i never tell alie you should check this I am sure you shocked to see this amazing offer...I'm Loving it!!!! ========================= http://www.homejobs7.com
 
Featured content