New Alzheimer s treatment fully restores memory function

32.14% credibility
 
Related

Japan s Cat Island Asks Internet For Food, Gets More Than They Can Store

Stuff
874 points

The schoolboy, 16, who will live with a Russian porn star in a hotel for a month

Stuff
4376 points



Most recent

"La última Paciente" se ensaya, pronto se estrenará en el Teatro Nuevo Versalles

Benjamin Bernal
16 points

La última paciente. Teatro Nuevo Versalles. Conozca a Alejandro Faugier, actor y director

Benjamin Bernal
12 points

Hilton reconoce 20 años de logros de Chrystian De La Barrera

Comunicaciones
12 points

¿Por qué el ciclismo indoor se ha puesto tan de moda?

Saludables
10 points

La última Paciente, en el teatro Nuevo Versalles. Conozca a Xareni Aguilar

Benjamin Bernal
12 points

¿Ante qué casos es recomendable acudir a un perito arquitecto?

MaríaGeek
18 points

LA IDEOLOGÍA INTERNACIONAL CONSUMISTA CONTRA LA COMUNISTA

Octavio Cruz Gonzalez
16 points

El futuro de la gestión del almacenamiento

Patricia Amaya Comunicaciones
12 points

El Hijo de las aguas y el hermano de los Vientos.

Pablo Emilio Obando Acosta
14 points

Kingston dice adiós a las transferencias lentas para creadores de contenido

Prensa
14 points
SHARE
TWEET
Australian researchers have come up with a non-invasive ultrasound technology that clears the brain of neurotoxic amyloid plaques - structures that are responsible for memory loss and a decline in cognitive function in Alzheimer’s patients.

New Alzheimer   s treatment fully restores memory function

If a person has Alzheimer’s disease, it’s usually the result of a build-up of two types of lesions - amyloid plaques, and neurofibrillary tangles. Amyloid plaques sit between the neurons and end up as dense clusters of beta-amyloid molecules, a sticky type of protein that clumps together and forms plaques.

Neurofibrillary tangles are found inside the neurons of the brain, and they’re caused by defective tau proteins that clump up into a thick, insoluble mass. This causes tiny filaments called microtubules to get all twisted, which disrupts the transportation of essential materials such as nutrients and organelles along them, just like when you twist up the vacuum cleaner tube.

As we don’t have any kind of vaccine or preventative measure for Alzheimer’s - a disease that affects 343,000 people in Australia, and 50 million worldwide - it’s been a race to figure out how best to treat it, starting with how to clear the build-up of defective beta-amyloid and tau proteins from a patient’s brain. Now a team from the Queensland Brain Institute (QBI) at the University of Queensland have come up with a pretty promising solution for removing the former.

Publishing in Science Translational Medicine, the team describes the technique as using a particular type of ultrasound called a focused therapeutic ultrasound, which non-invasively beams sound waves into the brain tissue. By oscillating super-fast, these sound waves are able to gently open up the blood-brain barrier, which is a layer that protects the brain against bacteria, and stimulate the brain’s microglial cells to activate. Microglila cells are basically waste-removal cells, so they’re able to clear out the toxic beta-amyloid clumps that are responsible for the worst symptoms of Alzheimer’s.

The team reports fully restoring the memory function of 75 percent of the mice they tested it on, with zero damage to the surrounding brain tissue. They found that the treated mice displayed improved performance in three memory tasks - a maze, a test to get them to recognise new objects, and one to get them to remember the places they should avoid.

"We’re extremely excited by this innovation of treating Alzheimer’s without using drug therapeutics," one of the team, Jürgen Götz, said in a press release. "The word ‘breakthrough’ is often misused, but in this case I think this really does fundamentally change our understanding of how to treat this disease, and I foresee a great future for this approach."

The team says they’re planning on starting trials with higher animal models, such as sheep, and hope to get their human trials underway in 2017.

Fuente: www.sciencealert.com
SHARE
TWEET
To comment you must log in with your account or sign up!

Comentarios más recientes
jolia
Ev­­­er­­­yb­­­od­­­y c­­­an e­­­ar­­­n 250$+ da­­­il­­­y... Y­­­o­­­u c­­­an e­­­arn f­­­ro­­­m 6000-12000 a m­­­on­­­th o­­­r ev­­­en m­­­or­­­e if y­­­ou w­­­or­­­k a­­­s a­­­ fu­­­ll ti­­­me j­­ob...I­­­t's ea­­­sy, j­­­us­­­t fo­­­ll­­­ow in­­­str­­­ucti­­­ons o­­­n th­­­is pa­­­ge, re­­­ad i­­­t car­­­ef­­­u­­­l­­­ly f­­­ro­­­m st­­­ar­­­t t­­­o f­­­in­­­i­­­sh..I­­­t's ­­­a fl­­­exi­­­b­­­l­­­e j­­­o­­­b b­­­u­­­t a g­­­o­­­o­­­d e­­­a­­­n­­­i­­­ng o­­­pp­­­or­­­t­­­u­­­n­­­i­­­t­­­y.......if u want good job g­­­o t­­­o t­­­hi­­­s si­­­te ho­­­me t­­­a­­­b f­­­or m­­­or­­­e d­­­et­­­a­­­i­­­l CLICK THIS LINK==========w­­w­­w.4­­n­­­e­­­w-w­­­a­­­y.c­­o­­m==========
 
Featured content