Scientists closer to drug that cuts nicotine dependence

 
Related

Karma and conscience

Health at home
226 points

8 syphilis symptoms in women that are straight-up terrifying

Health at home
226 points



Most recent

Doing this exercises you can reduce sugar cravings

About everything
20 points

Man who murdered over 70 serial killers, now walks free

You have to know
58 points

You have to watch the reaction when a puppy meets firefighter who saved her

Amazing histories
44 points
SHARE
TWEET
Researchers say they've created an enzyme that might one day reduce nicotine cravings in smokers.

Scientists closer to drug that cuts nicotine dependence

The scientists gave the enzyme to nicotine-dependent rats and found it broke down nicotine in the bloodstream before it could reach the brain.

This quickly reduced the rats' nicotine dependence. It also prevented them from relapsing when they again had access to nicotine, according to the study.

"This is a very exciting approach because it can reduce nicotine dependence without inducing cravings and other severe withdrawal symptoms," said principal investigator Olivier George. He's an associate professor at Scripps Research Institute in La Jolla, California.

U.S. FDA cracks down on electronic cigarette producers

The U.S. Food and Drug Administration sent letters to 21 electronic cigarette manufacturers seeking information to assess whether the products are being marketed illegally.

Also, the enzyme "works in the bloodstream, not the brain, so its side-effects should be minimal," George added in an institute news release.

Nicotine dependence is what makes it so difficult for people to quit smoking. Preventing the nicotine in tobacco from reaching the brain has long been seen as a promising way of reducing dependence, but previous efforts haven't resulted in drugs that reduce blood levels of nicotine enough to be effective.

The enzyme tested in this study is called NicA2-J1. It's based on a natural enzyme produced by the bacterium Pseudomonas putida, but was modified to boost its potency, staying time in the blood, and other features to fight nicotine dependence.

The researchers plan to continue to improve the enzyme's properties with the goal of eventually conducting human clinical trials. However, it's important to note that results of animal trials aren't always replicable in humans.

The findings were published online Octber 17 in Science Advances.

Fuente: www.health24.com
SHARE
TWEET
To comment you must log in with your account or sign up!
Featured content